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Growing importance of natural products research
Lastly, NBDHEX is not a substrate for the P-glycoprotein export pump but promotes cysteine-dependent apoptosis in cells overexpressing P-gp and may be used to treat P-gp-positive tumors [165]
Given that inflammatory insults do not cause depressive symptomology when KP enzymes are blocked, one can surmise that the generation of KP metabolites is a mandatory event preceding the induction of MDD manifestation [117]
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