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Optimal tumor cell adhesion is observed under low flow conditions, typically encountered in the venous but not arterial system [228, 229]

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While these compounds show promise in preclinical studies, their safety and efficacy in humans remain to be established through proper clinical trials

To determine the impact of MTX on cell metabolism, cell lines underwent unsupervised global metabolic profiling by 1 H-NMR in either the presence or in the absence of the drug (a representative 1 H-NMR spectrum is shown in Supplementary Figure 2 )