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Factors to consider prior to taking Buprenorphine and Naloxone include allergies, age of the patient, breastfeeding, potential drug interactions or medical conditions that can become complicated by adding use of this drug, such as asthma, alcohol addiction, heart disease, mental health issues, head injury, urinary problems or stomach problems

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The important principle is maintaining roughly seven-day intervals between doses rather than exact calendar timing

Over time, this can lead to premature shedding and a lack of new growth