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Serum levels of IS and p-CS were significantly lowered, and data obtained indicated that the Lm-low dose group (10 7 CFUs) demonstrated greater efficacy in mitigating CKD progression and restoring the gut microbiota balance as against the Lm-high dose group (10 9 CFUs) (Huang et al., 2021)

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Ferroptotic cell death is characterized by the release of damage-associated molecular patterns (DAMPs) that trigger immunogenicity and neuroinflammation, hallmarks of both HAND and AD (Smail and Brew, 2018

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The VSIG4 gene deletion reduces lactate and H3K18la production, thereby decreasing STAT3-mediated SPP1 transcription and disrupting intercellular interactions between TAMs and neutrophils, improving the immunosuppressive microenvironment (74)

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