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Via screening 18 HDACs for the potential delactylase activity, Zhao and colleagues reported that HDAC1-3 and SIRT1-3 could cleave L-lactyllysine marks in vitro [95], especially for nuclear HDAC1-3 serving as the most robust delactylases, suggesting a critical role of HDAC1-3 for the removal of histone lactylation [95]

Where indicated (see Results, specifically concerning the association between the GST-Pi gradient and 12-month eGFR), this was by the method of Bonferroni, accounting for 41 comparisons (biomarkers specified in advance, accounting for where markers were measured at more than one timepoint, and the associated gradient)

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Efficacy and safety of berberine for dyslipidaemias: a systematic review and meta-analysis of randomized clinical trials