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Changes in hormones can also cause you to gain belly fat, and research has found that extra abdominal weight can lead to increased inflammation, which affects metabolism

Indeed, in mice, those with obesity caused by diet or genetic factors showed exacerbation of AHR and neutrophilic airway inflammation with increasing expression of IL-17A in the lung (75, 76) and Th17 lymphocytes, suggesting that type 3 innate lymphoid cells might be responsible for worsening the AHR and airway inflammation in such animals (77, 78)

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The HPA axis includes the Hypothalamus (brain region), Pituitary (a gland in the brain), and Adrenals (produces adrenalin and cortisol)