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By analogy with semaglutide (where the STEP-4 withdrawal trial demonstrated substantial weight regain within 12 months of discontinuation), researchers should anticipate that weight regain is likely following cessation of any GLP-1 class compound, including retatrutide

Now they're taking into account all the drugs that don't make it to the finish line

PCP Debate As GLP-1 prescribing spreads across primary care, cardiology, and other specialties, a fundamental question remains unresolved: who bears primary clinical responsibility for these patients

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