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Understanding why they happen can help you make informed choices about your portions and timing

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Drug concentration, overall charge, molecular physicochemical attributes, molecular volume, solubility partition coefficient, and area of skin employed for application all affect iontophoretic drug delivery, and the effectiveness of iontophoretic transfer is also influenced by skin surface intactness, stratum thickness, and area-specific differences in blood flow in different areas of the skin [94,95]