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Safety and efficacy of semaglutide once weekly vs sitagliptin once daily, both as monotherapy in Japanese people with type 2 diabetes

A composite of major kidney disease events was the primary outcome of the trial and consisted of onset of kidney failure, a 50% or greater reduction in eGFR from baseline, or kidney or CV-related mortality

This means preserving muscle during weight loss with semaglutide may be important to reduce insulin resistance and prevent frailty in people with obesity. Haines said that more studies are needed to find the best way to lose fat but keep muscle when using GLP-1 medications

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