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b Key inclusion criteria for the STEP 2 trial were age 18 years, type 2 diabetes diagnosed 180 days prior, BMI 27 kg/m 2 , HbA 1c 7%10% (5386 mmol/mol) and treatment with diet and exercise alone or stable treatment with metformin, sulphonylurea, sodiumglucose cotransporter2 inhibitor, glitazone as singleagent therapy or 3 agents for diabetes according to local label

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Systemic treatment with the insulin-receptor antagonist, S961, can induce -cell-specific senescence and hyperglycemia in 28-week-old C57BL/6J mice 1,12