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The table pairs indicators with what each may suggest: stable fasting glucose and HbA1c point to improved baseline metabolic health, sustained appetite reduction off-medication suggests strong lifestyle adaptation, gastrointestinal tolerance challenges may warrant a change or temporary pause, and improving cardiovascular markers indicate the treatment is working rather than that stopping is safe

To reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight

What Happens When You Stop Taking Semaglutide

Retatrutide may also be suitable, but this will depend on future approvals and guidance