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From the early inklings of an incretin factor in the 1900s, through the molecular identification of GLP-1 in the 1980s, to the ingenious harnessing of a lizards venom peptide in the 1990s each chapter built the foundation for what is now a pillar of modern therapy for metabolic diseases

The Phase 2 data (14.8% weight loss at 13 weeks with reported muscle preservation) are remarkable if confirmed, suggesting rapid, substantial weight loss that approaches semaglutide's 68-week results in just a fraction of the time

However, no improvement in clinical disease score could be observed compared to wild-type control mice (Fig

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