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This reaction primarily occurs in polyunsaturated fatty acids (PUFAs) due to their multiple double bonds, which make them more susceptible to free radical attack ( Figure 1 2.1 Membrane damage induced by lipid peroxidation Lipid peroxidation is one of the key mechanisms in muscle atrophy

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[23] GSTs have a role in the bioactivation process of clopidogrel prodrug

demonstrated that 1-palmitoyl-2-(5-oxo-valeroyl)-sn-glycero-3-phosphocholine elevates oxidative stress and disrupts mitochondrial function in VSMCs, thereby promoting lipid peroxidation and inducing ferroptosis in VSMCs, ultimately contributing to vascular calcification