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131 The production of RONS increases the sensitivity of cells to genotoxic drugs by decreasing the activity of DNA-PKcs, hindering repair processes, and leading to the accumulation of DSBs

In this study, healthy human adults, which consisted of the same participants, same dose, and same controlled conditions, had their blood NAD+ levels increase by 161% after 8 days of supplementing with 1,200 mg/day, compared to an increase in blood NAD+ of 67% for NMN at the same dose in the same participants

Injectable peptides (BPC-157, TB-500) create stronger signaling effects and targeted delivery

Mechanism of action Disrupts FOXO4p53 interaction in senescent cells