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Non-megaloblastic anemia is caused by: Alcoholism Myelodysplastic syndrome (precursor cells that form blood cells in the bone marrow become abnormal) Liver diseases Obstructive jaundice Bone marrow failure Hypothyroidism Splenectomy Chronic obstructive pulmonary disease (COPD) QUESTION See Answer How to diagnose macrocytic anemia Macrocytic anemia is mostly asymptomatic, and the condition is typically diagnosed during routine blood work