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As a medication, we applied BPC 157 (10 g/kg, 10 ng/kg), L-NAME (5 mg/kg), L-arginine (100 mg/kg) alone and/or combined, intravenously, immediately after intravenous heparin administration, while controls received simultaneously an equivolume of saline (0.5 ml/kg intravenously)

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The spent variant arises after the molecule has performed its function

It was hypothesized that the lack of activity was due to the increased hydrophilicity provided by the sulfur-containing bridging unit when compared to the control analog used, lipobactin, in which the lipid is attached directly to the N -terminus