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When the bodys weight-defence mechanisms are bypassed or suppressed, whether through surgery or medications like semaglutide or tirzepatide, it appears to trigger changes in how food is perceived and prioritised by the brain." These changes can range from mild shifts in food preference to more intense food aversions

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It was originally developed for anxiety and cognitive enhancement, but its immune-modulating properties make it relevant to autoimmune conditions with neuropsychiatric components