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Plan Dose-Finding Studies: Design and execute systematic pilot and dose-response studies to empirically determine the optimal dosage for your specific research model and objectives

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Current Neuropharmacology, 11 (3), 315-335

Vitamin B12 can then be absorbed into the bloodstream via endocytosis in the distal ileum, or by passive diffusion in the absence of intrinsic factor.2 Pernicious anemia (an autoimmune disease) affects the gastric mucosa, leading to destruction of parietal cells and failure to produce intrinsic factor, resulting in vitamin B12 malabsorption and eventually deficiency