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147 Additionally, in the middle cerebral artery occlusion (MCAO) stroke model of mice, Li + can significantly attenuate GSDMD-mediated glial pyroptosis by regulating the AKT/GSK3/TCF4/-catenin signaling pathway, in which, the activation of AKT induced by Li + can also increase the phosphorylation of FoxO3a and promote the transportation of FoxO3a from nucleus into cytoplasm, the reduced FoxO3a in nucleus dissolves its competition with TCF4 in order to confirm more -catenin/TCF4 complex
As well as further testing for type 2 diabetes, overweight, and obesity, they will also be seeing how its effectiveness and safety compare with tirzepatide (brand names Mounjaro, Zepbound)
Ismail Kimji, MD, FRCPC, as medical reviewer
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