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The effects of gut microecological prescription on gut microbiota, metabolites, and molecular mechanisms in AKI and CKD The modulation of intestinal microbiota through probiotics, prebiotics, and symbiotic bacteria has emerged as a potential therapeutic approach for managing AKI [170, 174]

Cyclooxygenase-2 (COX-2) is an enzyme typically absent in normal tissue but becomes activated and expressed when triggered by factors such as tumors or infections

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[225] Diseases of the optic nerve, including ON, ischemic optic neuropathy, traumatic optic neuropathy, and glaucoma, can lead to retinal ganglion cell death, often through apoptosis and the generation of ROS