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The present invention also discloses the detection of the optical purity of L-3-cyano -2 - hydroxypropyl trimethyl ammonium and the content of its D-isomer in the intermediate mixture, wherein the detection method includes the following steps: ( 1 ) Preparation of the derivatization reagent solution: D-type or L-type optical pure compound of formula (II) is dissolved in solvent above to prepare a 0.01 100 mg / ml solution under the dark conditions

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A higher initial degree of tinnitus corresponded to a prolonged recovery time

10.1186/s13098-025-01623-w 57 ParsiP.SaharkhizS.FaraniM