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The development of GLP-1 RA-specific medical nutrition therapy (MNT) protocols, and the active involvement of an RDN in optimizing key dietary recommendations, including ensuring adequate protein intake (based on g/kg body weight rather than percentage of total energy), increasing fiber intake, and reducing saturated fat intake, is important

Abbreviations AE adverse event AS Alstrm syndrome BBS Bardet-Biedl syndrome BMI body mass index CI confidence interval CRIBBS Clinical Registry Investigating Bardet-Biedl Syndrome FAS full analysis set GLP1 glucagon-like peptide 1 HRQoL health-related quality of life IWQoL-Lite Impact of Weight on Quality of Life Lite LEPR leptin receptor LTE long-term extension MC4R melanocortin-4 receptor MID minimally important difference PCSK1 proprotein convertase subtilisin/kexin type 1 PedsQL Pediatric Quality of Life Inventory POMC pro-opiomelanocortin PRO patient-reported outcome QoL quality of life RCT randomized controlled trial SAE serious adverse event SAS safety analysis set SC subcutaneous SD standard deviation TEAE treatment-emergent adverse event Appendix 1