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Efficacy of Different Routes of Vitamin B12 Supplementation for the Treatment of Patients with Vitamin B12 Deficiency: A Systematic Review and Network Meta-Analysis. Irish Journal of Medical Science, 17 Jan

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Our team has observed that for studies focusing on long-term, sustained NNMT inhibition where slight variations in peak plasma concentration aren't catastrophic, the oral route might be sufficient

Supplements may be particularly useful for those with dietary restrictions, absorption issues or increased nutritional needs