Same as GLP-1: patients with thyroid cancer history, MEN2, severe GI disorders, or known allergies to tirzepatide
The studies identified the following effects relating to the therapeutic effects of GLP-1 RAs in PCOS animal models: metabolic effects (reduced body weight, improved insulin sensitivity, decreased HOMA-IR, and improved glucose tolerance), hormonal regulation (decreased testosterone, LH/FSH ratio, and increased SHBG) and ovarian effects (reduced cystic follicles, increased corpus luteum formation, and restored regular estrous cycles)
The drug, which helps people feel more full and therefore reduce their caloric intake, is administered as a shot, and costs around $900 a month without insurance in the United States
discuss options with your clinician