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Orforglipron is the first small molecule GLP-1 to complete a Phase III trial, lowering A1C by an average of 1.3% to 1.6% across doses

Patients were initiated on DPP-4i, sulfonylurea, SGLT-2i, or GLP-1 RA

The classic medication in the first-generation category is Benadryl (diphenhydramine)

This includes if someone has HIV, has taken medication for HIV, has had a blood or blood marrow-related cancer, suffered from hepatitis since turning 11, has been infected with parasites responsible for babesiosis or Chagas disease, has taken etretinate for psoriasis (a skin disease), has been identified as having risk factors for a brain disease known as variant Creutzfeldt-Jakob disease (CJD), or has blood relatives suffering from this disease