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The recommended dosage is 12 to 15 grams of dried fruit or 200 to 400 mg of silymarin extract

Beneficial effects have also been reported by the use of melatonin in brain-injured mice 24 h after reperfusion with a selective action involving caspases 3 inhibition 40

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People should consult a doctor about easy bruising if: bruising occurs more often or more severely than before they have other symptoms, such as fever, low energy, or skin changes they are taking medication and begin bruising more easily bruises are slow to heal they notice petechiae small red spots resembling a rash under the skin they develop purpura purple patches under the skin A person should seek emergency help if a large bruise develops after a trauma, especially if they also have lightheadedness or dizziness