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As pharmacist Suzy Cohen says in her book Drug Muggers: Which Medications Are Robbing Your Body of Essential Nutrients and Natural Ways to Restore Them, Any medication, whether its listed here or not, that goes through your liver can increase your requirements for this nutrient

Mutations in UBQLN2 have recently been shown to cause dominant X-linked inheritance of ALS/dementia 126

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(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)