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Most incretin-based drugs were also beneficial on total and LDL-cholesterol, with the greatest reduction observed with retatrutide (12.8% and 16.5%, respectively)

GLP-1 and addiction pathways GLP-1 is a hormone released from intestinal cells after food intake

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Moreover, ebselen increased the expression of GPX2 and GPX4 in SGNs after peroxynitrite injury (Supplementary Figure 3), which is consistent with previous studies that ebselen can increase the expression of GPX2 or GPX4 in rat stomach (Xu et al., 2018), or cochlea ( With regard to how GPX1 influences the apoptotic outcome, the pieces of evidence indicate that GPX1 may influence several steps in apoptotic cascades via regulating oxidant accumulation