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Hypothyroidism can develop when a significant number of follicular cells, which produce and secrete thyroxine and triiodothyronine, are destroyed
FLuc mRNA without template encoded poly(A) tail was ligated to a scramble (non-polyA) stem oligo with 3 end modifications (six phosphorothioate/2MOE at 3 and terminal dideoxycytidine modifications) and internal alkyne (5-octadiynyl deoxyuridine or OU), with or without conjugation to 5 azide labeled scramble or poly(A) branches with 3 end modifications (the same as the stem oligo)
G., Radhakrishna, H., and Peters, P
May help modulate low-grade inflammation associated with metabolic stress and aging
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