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A review of creatine supplementation in age-related diseases: more than a supplement for athletes

But their translation into routine practice necessitates rigorous evaluation of safety, durability of efficacy, and patient heterogeneity-factors that remain insufficiently addressed to date ( 4.1 Liver-selective THR agonists for metabolic and fibrotic correction Emerging pharmacological strategies have increasingly targeted THR signaling, particularly in the treatment of NASH and progressive MAFLD (158, 159)

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