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Additionally, these agents mitigate oxidative stress through upregulation of antioxidant pathways, including NRF2 (nuclear factor erythroid 2-related factor 2), enhance mitochondrial function, and reduce pathological -synuclein aggregation [56, 57]

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Average care includes about 4.1 provider visits in the first year, yet adherence drops and only 4.7% follow up at 24 months, so set a plan for ongoing check-ins and 60 minutes of daily activity plus 2 to 3 weekly resistance sessions to preserve gains