Consistent with these findings, previous in vitro studies showed that OXM is a full agonist at the GCGR and GLP-1R but is 3-fold less potent at the GCGR than native glucagon and 100-fold less potent at the GLP-1R than native GLP-1, in terms of activating cAMP accumulation ( Despite convincing data suggesting the central role of GLP-1R signalling in the food intake reduction effects of OXM, there were still some unexplained effects of the gut hormone including increased energy expenditure, suggesting a GLP-1R independent mechanism of action ( in vitro in addition to enhanced metabolic rate in humans had been previously shown ( Glp1r -/- mice, suggesting that both GLP-1R and GCGR are required for weight loss to occur
Injections are more effective for those with absorption issues or severe deficiencies, while pills may suffice for mild deficiencies
For GLP-1 medications, insurers may require evidence that the patient has tried other treatments or that the medication is essential for managing weight loss in the presence of other conditions like type 2 diabetes, hypertension, or cardiovascular disease
Synthetic comparison of the 7 peptides available at French Peptides, classified by mechanism, selectivity and level of evidence
