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In REDEFINE 1, the combination produced larger average weight loss than either compound alone 20.4% with CagriSema versus 14.9% with semaglutide alone and 11.5% with cagrilintide alone, all under the treatment-policy estimand

The levels of HIF-1 and HO-1 were raised in diabetic kidney tissue exacerbated tubular iron accumulation, enhanced the lipid peroxidation response, and augmented the generation of ROS