As an electrophilic chemical, ITCs might react covalently with the thiol groups of (proteins and) glutathione in plants, similar to what has been demonstrated in different in vitro systems 38,77,78 as well as in insects feeding on GSL or ITC diets 79,80
Off-label benefits of GLP-1s are also being evaluated, some of which include improvement in inflammation and arthritis issues, metabolic disorders, addiction disorders (gambling, alcoholism, drugs) and possible benefits for hormone-driven cancers
These analyses consistently supported the primary analysis results
While microneedle patches and advanced delivery technologies are under investigation in preclinical and early clinical studies, no products have completed the FDA approval process