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However, for individuals who require high doses or have difficulty absorbing the vitamin, injections may be a more practical option

To explore through an alternative strategy whether GLP-1R binding kinetics influence PM recycling and insulin secretion, we utilized the GLP-1R allosteric modulator 4-(3-( b enzyloxy)phenyl)-2-( e thylsulfinyl)-6-( t rifluoro-methyl) p yrimidine (BETP), which alters the residence time of orthosteric GLP-1R agonists 45

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Semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are FDA-approved and widely prescribed, but their sex-specific mechanisms in hormonal disease are still being actively characterised