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Moreover, studies employing germ-free models and probiotic supplementation provide compelling evidence for a causative relationship between microbial metabolites and cerebral health (452)

The author thanks the Deutsche Forschungsgemeinschaft (SFB 1192) and the Else Krner Fresenius Stiftung for continuous support

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The peptide's structure contains the 4-10 melanocortin receptor binding region common to -MSH and adrenocorticotropin (ACTH), but incorporates a lactam bridge between amino acids 4 and 10, along with specific amino acid substitutions (Nle4, Asp5, D-Phe7, Lys10) that enhance receptor binding affinity and metabolic stability