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Published Research on 5-Amino-1MQ Foundational DIO Mouse Study Neelakantan et al., Biochemical Pharmacology (2018) This paper introduced 5-Amino-1MQ as a selective and membrane-permeable small molecule inhibitor of NNMT and tested it in 3T3-L1 adipocytes and in male C57BL/6J mice maintained on a high-fat diet

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Our findings provide the mechanism by which these asthma drugs attenuated the neurotoxicity of amyloid peptide, damage to heart myocytes by hypoxia-reperfusion and gentamycin-triggered kidney damage, as previously reported by several other research teams

10.1126/sciadv.adf3026 84 PhamK.FrostS.ParikhK.PuvvulaN.OeungB.HeinrichE