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This is why the expiration date and beyond-use date exist, they tell you when degradation has likely progressed to a meaningful degree even if you cannot see it

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The optimal consumption is at least 30 minutes before or 90 minutes after a meal with 250 ml of still, lukewarm water or optionally with a teaspoon of omega-3 oil to increase bioavailability

Estudios con fluido gstrico simulado han demostrado conservacin de la integridad estructural a pH tan bajos como 1,5, atribuida a su secuencia rica en prolina resistente a la escisin por pepsina