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In preclinical studies, inhibition of AGE formation, or interventions that break their cross-linked structure, have been shown to delay the development of nephropathy, even without directly impacting blood sugar control (Forbes 2003)

401 A meta-analysis of five randomized controlled trials with a total of more than 11,000 participants found colchicine reduced the risk of major thromboembolic cardiovascular events in patients with coronary artery disease, but had no effect on cardiovascular mortality

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Patio-Cardona, S., Garrido-Miguel, M., Pascual-Morena, C., Berlanga-Macas, C., Lucern-Lucas-Torres, M., Alfaro-Gonzlez, S., & Martnez-Garca, I