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Trends Pharmacol Sci (2019) 40:43045
As a single-center retrospective analysis, it may be subject to selection bias, and conclusions should be validated in large-scale multicenter prospective studies
However, its always advisable to consult with a healthcare provider before starting any new supplement, especially if you have underlying health conditions or are taking other medications
However, the researchers did note significant effects of the combination: We conclude that the choline-induced decrease in serum and urinary carnitine is buffered by carnitine preloading, and these supplements shift tissue partitioning of carnitine that favors fat mobilization, incomplete oxidation of fatty acids and disposal of their carbons in urine as acylcarnitines in humans. Yet, the researchers also used a dose that was much lower than the dose used in the animal studies
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