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Supporting this, data from our functional enrichment analysis of the transcriptome revealed notable upregulation of oxidative phosphorylation and the oxidative damage response in hepsin / mice treated with saline (data not shown)

Firstly, excessive accumulation of ROS within mesangial cells under chronic hyperglycemia can lead to cell death by activating mTOR, 66 sirtuin1, 67 and XBP1, 60 resulting in renal dysfunction

Schneider et al., Patterns of Polysubstance Use and Overdose Among People Who Inject Drugs in Baltimore, Maryland: A Latent Class Analysis, Drug and Alcohol Dependence 201 (2019): 71-77, N.C

When administered under professional supervision, glutathione is generally considered safe