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This study explores a new source of immunogenic polypeptides originating from a nonconventional open reading frame within human insulin mRNA, which can be targeted by cytotoxic CD8 + T cells present in individuals with T1D, potentially contributing to -cell destruction in the disease

For the outer thigh in lean patients, 45 degrees with a pinch is the safer choice

Data availability Publicly available data sets (GSE114691 58 , GSE25906 59 , and GSE10588 60 ) were analyzed in this study and the data are available via geo/

MT-II has additional modifications compared to MT-I, which broaden its receptor affinity and therapeutic spectrum