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In addressing the limitations of small molecules and biologicals, peptides that interfere with PPIs with a molecular weight ranging between 500 and 5000 Da have been developed 126

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To increase energy uptake, additional alternative metabolic fuels for the CNS and muscle also appear warranted and could include ketones and medium chain fats, but also metabolic intermediates, such as pyruvate, lactate, -ketoglutarate and others

These variables can introduce biases in the results, and we have discussed their potential impact in the results and discussion section