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Skin Discoloration or Hyperpigmentation : Long-term use of glutathione injections for skin lightening can result in unintended skin discoloration, uneven pigmentation, or hyperpigmentation

The two primary MTHFR variants are C677T (rs1801133) which substitutes valine for alanine at position 222, reducing enzyme activity by approximately 35% in heterozygotes and 70% in T/T homozygotes at physiological folate concentrations and A1298C (rs1801131) which substitutes glutamate for alanine at position 429, reducing activity by approximately 20% in heterozygotes, with compound heterozygosity (C677T + A1298C) producing effects between the two individual homozygous states

JPGN Rep 5(4):548551

76 LiP.GaoM.HuZ.XuT.ChenJ.MaY.et al (2021)