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3.4 Results of the in vitro TMA lyase inactivation test The fecal slurries were tested against all the lyophilized powders obtained during the production assays, and at 3 h after the beginning of the experiments, the supernatants were collected to assess the TMA-inhibitory activity

With new clinical trials of APR-246 commencing in multiple tumour streams 2 , our discovery of SLC7A11 expression as a robust companion biomarker, in addition to mut-p53 status, for APR-246, may facilitate selection and enrichment of patients with mut-p53 tumours who are most likely to respond to APR-246 therapy