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The PI3K-AKT pathway enhances muscle building and repair by increasing protein production and reducing protein breakdown

In addition, recent exploratory studies have found increased serum BDNF levels following holistic neuro-rehabilitative approaches, including computer-assisted cognitive enhancement in schizophrenia 20 , aerobic exercise in stroke 21 and mindfulness clinical trials in bipolar-disorder 22

The death rate from all causes of death for a population in a given time period

Moreover, the interplay between conserved signaling pathways, such as those implicated in aging (predominantly involving the PI3K-AKT route), and lesser known pathways, such as those mediated by biased G-protein coupled receptors and others even less known, may underpin the context-dependent actions characteristic of ILPs signaling