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Mild digestive upset has also been reported, particularly at higher doses

Metformin attenuated the progression of OA in an MIA-induced mouse model To further investigate the effect of metformin on OA progression, radiological assessments, histological analyses and plasma assays were conducted to evaluate subchondral bone remodeling, articular cartilage degradation, and inflammation at 8 weeks post-MIA injection

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In contrast, although Popular Pathways have gained increasing attention in recent years, less comprehensive research has been conducted, resulting in a limited number of genes on which natural products can act and consequently fewer identified natural products