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More recently, others have found elevated expression of the NAD + glycohydrolase enzyme CD38 in the ovary during reproductive ageing, and showed that blocking the degradation of NAD + through small molecule inhibition of CD38 can prolong female reproductive lifespan (Perrone et al, 2023

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APOE and Alzheimers Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimers Pathogenesis

To put that in context: a supplement being widely sold and self-administered for injury recovery has essentially one human study to its name in this area