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Internal proteins such as the polymerase subunits (PA, PB1, PB2), matrix and nucleoprotein can have conservation in sequence of 7797% within influenza A but much reduced conservation with influenza B species

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Tongue hyperpigmentation in Addison's disease typically presents as diffuse darkening of the tongue surface, often accompanied by pigmentation of other mucosal surfaces and skin creases, plus systemic symptoms like fatigue and weight loss