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FOXO4-DRI's well-characterized mechanism and expanding research applications position it as an essential research tool for advancing our understanding of senescence biology and developing next-generation approaches to studying aging and age-related diseases in laboratory settings

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They can affect cellular signaling pathways that produce antioxidant enzymes like SOD and catalase, which remove free radicals and minimize oxidative stress (183)

AICAR has been suggested to exert this potential